IVIg conducts DC-platelet nuptials.

and -thromboglobulin) supports a packing or sorting defect rather than a defect in protein synthesis.5,7 By analogy, mice lacking chondroitin sulfate have -granules deficient in PF4, -thromboglobulin, and platelet-derived growth factor because of a granule-packing defect9 and patients lacking the vesicle-sorting protein VPS33B have -granule deficiency.10 Defects in protein packing, vesicle trafficking, granule acidification, membrane retrieval, or protein processing could prevent normal granule maturation and result in shunting to a default pathway of constitutive secretion. The large number of genes that could potentially contribute to -granule maturation complicates identification of likely culprits from the long list of candidate genes located in the linked interval on chromosome 3. We can only hope that improvements in sequencing technologies will make identification of the causative gene in GPS more black and white. Conflict-of-interest disclosure: The author declares no competing financial interests. ■